Application
Follow the active instead of inferring it
Concentration of the active is what the process is for. Sampling gives it to you a few times per batch, after a delay, from one point in a vessel.
The measurement problem
API synthesis and formulation both turn on knowing how much active is present and in what state. The measurement is usually HPLC, which is accurate, slow and destructive of the sample it consumes — so it is taken sparingly, and the process between samples is a black box.
An inline reading does not replace HPLC. It sits between the HPLC points and tells you what happened there, which is where endpoints, exotherms and impurity formation actually live.
What a live reading changes
- Concentration of the active as a continuous curve through synthesis and formulation.
- Endpoints called on the curve rather than on a validated worst-case hold time.
- Dissolution kinetics evaluated from time-resolved absorbance at the relevant wavenumbers.
- Non-destructive measurement: the 0.1 mL void volume consumes almost nothing and sample integrity is preserved.
- IQ supplied, OQ and PQ run jointly, and every measurement stored as an immutable record.
Is this your measurement?
Send the stream, the concentration range and the decision it blocks. Where it makes sense we test on your own process samples first.